Your DNA is the core or the basis of your existence. It's the blueprint that makes you who you are.
It contains all information about how you look and function. A unique code that makes you a unique person.
Every piece of information has its place on your DNA in the form of genes. Every gene represents a specific characteristic.
Genes determine eye colour, but also your skin type and the way in which your skin ages. The analysis or reading of your genes therefore offers insights into your skin that cannot be discovered in any other way.
Blessed with 'good genes'?
We simply define "good genes" as genes that do not show defects. "Good genes" can exert their normal function within biological processes that determine skin parameters, such as elasticity, hydration, barrier function, antioxidant capacity,...
When genes contain defects or mutations, their function is disturbed. In most cases, this leads to an increased risk of accelerated skin aging.
Nomige tells you what your genes look like, what parameters you are at risk for and how we choose the right ingredients to compensate for these risks.
"We are living in exciting times in terms of skincare. Using your genes we can counteract skin ageing with the right ingredients "
Using a DIY DNA kit, you can collect your own DNA. Simply rub the inside of your cheek with a cotton swab to collect your saliva. Carefully follow the instructions for use. You can easily store your sample at room temperature for a few weeks before sending it back to us.
Once we receive your sample, and after your explicit permission, we will investigate your DNA in a certified laboratory. We determine your genetic skin profile by investigating different genes involved in the main skin properties. We identify the presence of mutations in these genes and inform you about your risk for accelerated skin aging.
How your DNA affects the ageing of your skin
By examining your DNA, we can gain more insights into your skin ageing process. In the lab we analyse several genes involved in collagen homeostasis, antioxidant protection, barrier function and skin hydration. Based on your DNA profile, we know what risks you are carrying and we develop products whose ingredients can counteract these risks.
Collagen is the most important structural protein of the extracellular matrix and is responsible for the firmness and elasticity of your skin. Collagen is created every time your skin renews itself (every 28 days). Sufficient production of collagen contributes to a beautiful and tighter skin.
Collagen is also broken down, this is a natural process. Breakdown or degradation can be accelerated under the influence of external stress factors such as UV light. It activates enzymes like matrix metalloproteinases (MMP) that 'eat away' the collagen. The balance between collagen production and degradation determines the velocity of the skin aging process.
When MMP genes show mutations or errors, they are "overactive" and break down collagen even faster. This creates an imbalance towards faster collagen breakdown which negatively affects the firmness and elasticity of your skin. We investigate mutations in different MMP genes and determine your risk of accelerated collagen degradation.
Tissue damage by free radicals is one of the main causes of accelerated skin ageing. Free radicals are formed due to external stress factors, such as tobacco, pollution or exposure to UV radiation.
We have a natural 'built-in' protection mechanism since our skin itself produces antioxidants that can neutralise free radicals before they cause damage. But when this defensive mechanism does not function properly, traces of skin aging will be more visible.
Nomige investigates how well your defense mechanism works by detecting mutations in the antioxidant genes such as superoxide dismutase (SOD-2) and glutathione peroxidase (GPX).
Hydration & barrier function
A well hydrated skin shows less wrinkles and is often less prone to irritation. A sensitive skin is the result of a disturbed skin barrier; one of which the intercellular lipids have some defects. As a result, not only irritants or allergens can penetrate the skin (from the outside to the inside), but water can also easily evaporate from the skin (from the inside to the outside). If this happens, skin dehydration occurs.
In addition, the moisture balance is also determined by molecules that can attract and transport water. Defects in these molecules also lead to a disturbed moisture balance and result in a dry, dehydrated skin.
Nomige investigates whether you have mutations in the genes that help keep the skin barrier intact and help control the moisture balance; namely Fillagrin (FLG) and Aquaporin-3 (AQ3)
- We work with an accredited genetic lab
- We stick to guidelines drawn up concerning privacy and data protection
- GMP production of DNA-based formulas
- We don’t use chemical preservatives or harmful ingredients